Introduction: Piperazine, a six membered nitrogen containing heterocycle, is of great
significance to the rational design of drugs. This moiety can be found in a plethora of well …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

Development of new medications is a lengthy and costly process, and drug repositioning
might help to shorten the development cycle. We present a machine learning (ML) workflow …

A series of chrysin derivatives were designed, synthesized, and evaluated for their
antibacterial activity against four different bacterial strains. We have synthesized new propyl …

Introduction Piperazine is a structural element present in drugs belonging to various
chemical classes and used for numerous different therapeutic applications; it has been …

A series of novel benzhydryl piperazine-coupled nitrobenzenesulfonamide hybrids were
synthesized with good to excellent yields. They were tested for in vitro inhibition of …

Neurological disorders are disease conditions related to the neurons and central nervous
system (CNS). Any structural, electrical, biochemical, and functional abnormalities in …

Intracellular protein delivery has been a major challenge due to various physiological
barriers including low proteolytic stability and poor membrane permeability of the biologics …

In this paper, we report the synthesis of quinoxaline‐isoxazole‐piperazine conjugates. The
anticancer activity was evaluated against three human cancer cell lines, including MCF‐7 …

The piperazine derivatives correspond to an extensive chemical class of compounds with
numerous neuropharmacological activities, including antidepressant (eg, nefazodone …