Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to
genome integrity, but information about how such lesions are processed and repaired is …

Fusion genes that are caused by chromosome translocations have been recognized for
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …

Chromatin acts as a key regulator of DNA‐related processes such as DNA damage repair.
Although ChIP‐chip is a powerful technique to provide high‐resolution maps of protein …

Summary Ataxia Telangiectasia Mutated (ATM) signaling is essential for the repair of a
subset of DNA double-strand breaks (DSBs); however, its precise role is unclear. Here, we …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA
repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin …