Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …

During hypoxic conditions, cells undergo critical adaptive responses that include the up-
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …

The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …

The vascular endothelium acts as a barrier between the blood flow and the inner lining of
the vessel wall, and it functions as a filtering machinery to filter out any unwanted transfer of …

The adaptive response to hypoxia involves the transcriptional induction of three transcription
factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which …

The cellular adaptive response to hypoxia relies on the expression of hypoxia-inducible
factors (HIFs), HIF-1 and HIF-2. HIFs regulate global gene expression changes during …

In living cells Reactive Oxygen Species (ROS) participate in intra-and inter-cellular signaling
and all cells contain specific systems that guard redox homeostasis. These systems contain …

It is extremely important to promote angiogenesis-dependent osteogenesis and ameliorate
bone loss for the prevention and treatment of osteoporosis (OP) development. Vitexin, as …

The microRNAs (miRNAs) are short non-coding RNAs (19–25 nt) that regulate the level of
gene expression at the post-transcriptional stage. Altered miRNAs expression can lead to …