Potential therapeutic targets and the role of technology in developing novel antileishmanial drugs
R Rajasekaran, YPP Chen - Drug discovery today, 2015 - Elsevier
Highlights•Anti-leishmanial drugs available today pose severe side effects and are not
affordable.•Identifying suitable drug target is essential for effective drug development.•Target …
affordable.•Identifying suitable drug target is essential for effective drug development.•Target …
Targeting pteridine reductase 1 and dihydrofolate reductase: the old is a new trend for leishmaniasis drug discovery
GM das Neves, LP Kagami, IL Gonçalves… - Future Medicinal …, 2019 - Taylor & Francis
Leishmaniasis is one of the major neglected tropical diseases in the world and it is
considered endemic in 88 countries. This disease is transmitted by a Leishmania spp …
considered endemic in 88 countries. This disease is transmitted by a Leishmania spp …
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
P Linciano, A Dawson, I Pöhner, DM Costa, MS Sá… - ACS …, 2017 - ACS Publications
Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis.
We investigated the potential of a previously identified class of thiadiazole inhibitors of …
We investigated the potential of a previously identified class of thiadiazole inhibitors of …
Potential of Pyrimidine Metabolism for Antitrypanosomal Drug Discovery
M Valente, AE Vidal… - … Analysis of Parasite …, 2016 - Wiley Online Library
Parasitic diseases, and particularly those caused by kinetoplastid parasites, are a major
public health problem especially in poor and nonindustrialized countries. Since currently …
public health problem especially in poor and nonindustrialized countries. Since currently …
Computational simulation and molecular design of novel anti-leishmanial drug
R Rajasekaran - 2017 - opal.latrobe.edu.au
Submission note: Submitted in total fulfilment of the requirements for the degree of Doctor of
Philosophy to the Department of Computer Science and Information Technology, School of …
Philosophy to the Department of Computer Science and Information Technology, School of …
[PDF][PDF] Maestro en Ciencias
DDEABS LINEAL - 2006 - ru.dgb.unam.mx
1.1 ANTECEDENTES La digestión anaerobia se ha ido afirmando en México como un
pretratamiento biológico efectivo para eliminar el 80% de la materia orgánica de las aguas …
pretratamiento biológico efectivo para eliminar el 80% de la materia orgánica de las aguas …