Background Inflammatory bowel diseases (IBD), comprising Crohn's disease and ulcerative
colitis (UC), are chronic conditions attributed to an aberrant immune response to luminal …

Despite advances in preoperative evaluation and postoperative care, intervention,
especially surgery, for relief of obstructive jaundice still carries high morbidity and mortality …

The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice
lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic …

The solubility of drugs in the gastrointestinal tract is very challenging to simulate with
artificial media due to the high complexity of human intestinal fluid (HIF). In particular, bile …

Background and aims Mechanisms of the progression from Barrett's oesophagus to
oesophageal adenocarcinoma (OA) are not fully understood. Bile acids may have an …

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an
association between altered bile acid (BA) metabolism, down‐regulation of farnesoid X …

Bile acids (BAs) have been implicated in regulation of intestinal epithelial signaling and
function. This study aimed to investigate the effects of hyodeoxycholic acid (HDCA) on …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
cystic fibrosis (CF), a multiorgan disease that exhibits diverse metabolic defects. However …

Scope To investigate whether deoxynivalenol (DON) can induce intestinal damage through
gut microbiota in mice. Methods and results Mice are orally administered DON (1 mg kg− 1 …

Objectives Necrotizing enterocolitis (NEC) is a catastrophic gastrointestinal emergency in
preterm infants, whose exact aetiology remains unknown. The role of lithocholic acid (LCA) …