Spike (S) protein cleavage is a crucial step in coronavirus infection. In this review, this
process is discussed, with particular focus on the novel coronavirus, severe acute …

Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …

Background and Aims Mutations in TERT (telomerase reverse transcriptase) promoter are
established gatekeepers in early hepatocarcinogenesis, but little is known about other …

The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive
and protective epithelial cell–cell interactions. Elevated matriptase is a consistent feature of …

Hepatocyte growth factor (HGF) promotes pleiotropic signaling through its specific receptor
tyrosine kinase, MET. As such, it has important roles in the regeneration of injured tissues …

Transmembrane protease serine 2 (TMPRSS2) is a membrane-bound protease expressed
in many human epithelial tissues, including the airway and lung. TMPRSS2-mediated …

Pericellular proteolysis provides a significant advantage to developing tumors through the
ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate …

Intestinal epithelial self-renewal is a tightly controlled process, which is critically dependent
on WNT signalling. Aberrant activation of the WNT pathway in intestinal stem cells (ISCs) …

The extracellular matrix (ECM) is a crucial component of the tumor microenvironment
involved in numerous cellular processes that contribute to cancer progression. It is …

Cell membrane‐bound serine proteases are important in the maintenance of physiological
homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the …