Asthma is a chronic respiratory disease characterized by variable airflow obstruction,
bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air …

Objectives To discuss the effect of certain factors on the occurrence of Adverse Drug
Reactions (ADRs). Data Sources A systematic review of the literature in the period between …

Background Previous studies have highlighted a relationship between reduction in rate of
exacerbations with therapies containing inhaled corticosteroids (ICS) and baseline blood …

Background Bronchial asthma is one of the most common chronic diseases in childhood,
with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming …

While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Abstract Randomized Controlled Trials (RCTs) are the “gold standard” for evaluating
treatment outcomes providing information on treatments “efficacy”. They are designed to test …

Rationale: One-quarter to one-third of individuals with asthma smoke, which may affect
response to therapy and contribute to poor asthma control. Objectives: To determine if the …

Purpose. The mechanisms for drug interactions with smoking and clinically significant
pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed …

Rationale: Active smoking in asthma is associated with worsening of symptoms, accelerated
decline in lung function, and impaired response to corticosteroids. Objectives: To examine …