Progress of microfluidic hydrogel‐based scaffolds and organ‐on‐chips for the cartilage tissue engineering
Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …
the globe. Numerous approaches have been employed to treat cartilage diseases …
[HTML][HTML] Bone/cartilage organoid on-chip: Construction strategy and application
Y Hu, H Zhang, S Wang, L Cao, F Zhou, Y Jing, J Su - Bioactive Materials, 2023 - Elsevier
The necessity of disease models for bone/cartilage related disorders is well-recognized, but
the barrier between ex-vivo cell culture, animal models and the real human body has been …
the barrier between ex-vivo cell culture, animal models and the real human body has been …
Chondrocyte hypertrophy in osteoarthritis: mechanistic studies and models for the identification of new therapeutic strategies
Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
Application and development of 3D bioprinting in cartilage tissue engineering
M Li, D Sun, J Zhang, Y Wang, Q Wei, Y Wang - Biomaterials Science, 2022 - pubs.rsc.org
Articular cartilage defects are one of the most common clinical diseases of bone articulation.
Early repair of damaged joint cartilage can effectively stop the progression of arthritis and …
Early repair of damaged joint cartilage can effectively stop the progression of arthritis and …
Synovial joint-on-a-chip for modeling arthritis: Progress, pitfalls, and potential
Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …
afflict a substantial proportion of the global population. However, current clinical …
Joint-on-chip platforms: entering a new era of in vitro models for arthritis
Arthritis affects millions of people worldwide. With only a few disease-modifying drugs
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …
[HTML][HTML] Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases
Summary Joint-on-a-chip (JOC) models are powerful tools that aid in osteoarthritis (OA)
research. These microfluidic devices apply emerging organ-on-a-chip technology to …
research. These microfluidic devices apply emerging organ-on-a-chip technology to …
Human organ-on-a-chip microphysiological systems to model musculoskeletal pathologies and accelerate therapeutic discovery
RE Ajalik, RG Alenchery, JS Cognetti… - … in Bioengineering and …, 2022 - frontiersin.org
Human Microphysiological Systems (hMPS), otherwise known as organ-and tissue-on-a-
chip models, are an emerging technology with the potential to replace in vivo animal studies …
chip models, are an emerging technology with the potential to replace in vivo animal studies …
[HTML][HTML] Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage
Movement is essential to our quality of life, and regulates cell behavior via mechanical
stimulation. Here, we report a monolithic microfluidic platform, in which engineered tissues …
stimulation. Here, we report a monolithic microfluidic platform, in which engineered tissues …
Endocytosis and exocytosis protect cells against severe membrane tension variations
The ability of cells to regulate their shape and volume is critical for many cell functions. How
endocytosis and exocytosis, as important ways of membrane trafficking, affect cellular …
endocytosis and exocytosis, as important ways of membrane trafficking, affect cellular …