Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …

In the brain, patterns of neural activity represent sensory information and store it in non
random synaptic connectivity. A prominent theoretical hypothesis states that assemblies …

Synaptic changes are hypothesized to underlie learning and memory formation in the brain.
But Hebbian synaptic plasticity of excitatory synapses on its own is unstable, leading to …

Cortical networks exhibit complex stimulus–response patterns that are based on specific
recurrent interactions between neurons. For example, the balance between excitatory and …

Synaptic inhibition is the mechanistic backbone of a suite of cortical functions, not the least
of which is maintaining overall network stability as well as modulating neuronal gain. Past …

Memories may be encoded in the brain via strongly interconnected groups of neurons,
called assemblies. The concept of Hebbian plasticity suggests that these assemblies are …

Experimental studies have shown that in cortical neurons, excitatory and inhibitory incoming
currents are strongly correlated, which is hypothesized to be essential for efficient …

Critical dynamics, characterized by scale-free neuronal avalanches, is thought to underlie
optimal function in the sensory cortices by maximizing information transmission, capacity …

Excitatory cortical neurons show clear tuning to stimulus features, but the tuning properties
of inhibitory neurons are ambiguous and have been the subject of a long debate. While …

Inhibitory interneurons regulate excitability, information flow, and plasticity in neural circuits.
Inhibitory synapses are also plastic and can be modified by changes in experience or …