Advances in microfluidics for single red blood cell analysis

GV Grigorev, AV Lebedev, X Wang, X Qian… - Biosensors, 2023 - mdpi.com
The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted
great interests in recent years to filter, trap, analyze, and release single erythrocytes for …

Blood plasma self-separation technologies during the self-driven flow in microfluidic platforms

Y Wang, BB Nunna, N Talukder, EE Etienne, ES Lee - Bioengineering, 2021 - mdpi.com
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical
analysis due to it contains various biomarkers. The majority of the blood plasma separation …

[HTML][HTML] Analysis of red blood cell partitioning at bifurcations in simulated microvascular networks

P Balogh, P Bagchi - Physics of Fluids, 2018 - pubs.aip.org
Partitioning of red blood cells (RBCs) at vascular bifurcations has been studied over many
decades using in vivo, in vitro, and theoretical models. These studies have shown that RBCs …

[HTML][HTML] In vitro investigations of red blood cell phase separation in a complex microchannel network

A Mantegazza, F Clavica, D Obrist - Biomicrofluidics, 2020 - pubs.aip.org
Microvascular networks feature a complex topology with multiple bifurcating vessels.
Nonuniform partitioning (phase separation) of red blood cells (RBCs) occurs at diverging …

Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation

MO Bernabeu, J Köry, JA Grogan… - Proceedings of the …, 2020 - National Acad Sciences
Oxygen heterogeneity in solid tumors is recognized as a limiting factor for therapeutic
efficacy. This heterogeneity arises from the abnormal vascular structure of the tumor, but the …

Glomerular microcirculation: Implications for diabetes, preeclampsia, and kidney injury

MS Goligorsky - Acta Physiologica, 2023 - Wiley Online Library
This review outlines the features of tandem regulation of glomerular microcirculation by
autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points …

Red blood cell lingering modulates hematocrit distribution in the microcirculation

Y Rashidi, G Simionato, Q Zhou, T John, A Kihm… - Biophysical …, 2023 - cell.com
The distribution of red blood cells (RBCs) in the microcirculation determines the oxygen
delivery and solute transport to tissues. This process relies on the partitioning of RBCs at …

The coronary capillary bed and its role in blood flow and oxygen delivery: A review

RJ Tomanek - The Anatomical Record, 2022 - Wiley Online Library
The assumption that the coronary capillary blood flow is exclusively regulated by
precapillary vessels is not supported by recent data. Rather, the complex coronary capillary …

A homogenized two-phase computational framework for meso-and macroscale blood flow simulations

A Karmakar, GW Burgreen, G Rydquist… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective Owing to the complexity of physics linked with blood flow
and its associated phenomena, appropriate modeling of the multi-constituent rheology of …

PyOIF: Computational tool for modelling of multi-cell flows in complex geometries

I Jančigová, K Kovalčíková, R Weeber… - PLOS Computational …, 2020 - journals.plos.org
A user ready, well documented software package PyOIF contains an implementation of a
robust validated computational model for cell flow modelling. The software is capable of …