Untethered miniature robots enable targeted delivery and therapy deep inside the
gastrointestinal tract in a minimally invasive manner. By combining actuation systems and …

The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …

The modern day drug delivery technology is only 60 years old. During this period numerous
drug delivery systems have been developed. The first generation (1950–1980) has been …

Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were
investigated in two studies with each 10 healthy human subjects using the IntelliCap® …

Consumers are increasingly interested in decreasing their dietary intake of animal-based
food products, due to health, sustainability, and ethical concerns. For this reason, the food …

Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in
the clinical setting. Due to the rising number of compounds having solubility issues, finding …

Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to
improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially …

The solubility behaviour of drugs remains one of the most challenging aspects in formulation
development. With the advent of combinatorial chemistry and high throughput screening, the …

This tutorial review summarises different aspects of cooperativity in supramolecular
complexes. We propose a systematic categorisation of cooperativity into cooperative …

The prodrug concept has been used to improve undesirable properties of drugs since the
late 19th century, although it was only at the end of the 1950s that the actual term prodrug …