About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …

Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of
Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant …

The Plasmodium falciparum dihydrofolate reductase (PfDHFR) and dihydroorotate
dehydrogenase (PfDHODH) are essential for Plasmodium falciparum growth and …

Natural products have made a crucial and unique contribution to human health, and this is
especially true in the case of malaria, where the natural products quinine and artemisinin …

Abstract Cryptolepine (1, 5-methyl-10 H-indolo [3, 2-b] quinoline), an indoloquinoline
alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) Schltr (family …

Lyme disease is the most common vector-borne disease in the US and Europe. Although the
current recommended Lyme antibiotic treatment is effective for the majority of Lyme disease …

Background Optimal adoption of the malaria transmission-blocking strategy is currently
limited by lack of safe and efficacious drugs. This has sparked the exploration of different …

Malaria elimination requires interventions able to target both the asexual blood stage (ABS)
parasites and transmissible gametocyte stages of Plasmodium falciparum. Lead antimalarial …

Human babesiosis is a CDC reportable disease in the United States and is recognized as
an emerging health risk in multiple parts of the world. The current treatment for human …