Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate
nervous system are incompletely understood. Here, we provide evidence of a global …

The inflammatory process in the human body is a physiological response involving many
cellular types and mediators. It results in scar formation to separate the damaged area from …

Neurons born in the embryo can undergo a protracted period of maturation lasting well into
postnatal life. How gene expression changes are regulated during maturation and whether …

Spinal cord interneurons play critical roles shaping motor output, but their precise identity
and connectivity remain unclear. Focusing on the V1 interneuron cardinal class we defined …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease selectively targeting
motor neurons in the brain and spinal cord. The reasons for differential motor neuron …

V2a interneurons are located in the hindbrain and spinal cord, where they provide rhythmic
input to major motor control centers. Many of the phenotypic properties and functions of …

Many RNA-binding proteins (RBPs) are linked to the dysregulation of RNA metabolism in
motor neuron diseases (MNDs). However, the molecular mechanisms underlying MN …