Polymer–drug conjugate therapeutics: advances, insights and prospects
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
Rational design of cancer nanomedicine: nanoproperty integration and synchronization
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
W Zhang, X Hu, Q Shen, D Xing - Nature communications, 2019 - nature.com
Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …
Precise nanomedicine for intelligent therapy of cancer
Precise nanomedicine has been extensively explored for efficient cancer imaging and
targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and …
targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and …
Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
Real-time tracking and in vivo visualization of β-galactosidase activity in colorectal tumor with a ratiometric near-infrared fluorescent probe
Development of “smart” noninvasive bioimaging probes for trapping specific enzyme
activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is …
activities is highly desirable for cancer therapy in vivo. Given that β-galactosidase (β-gal) is …
[HTML][HTML] Sustained delivery approaches to improving adaptive immune responses
The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …
and protecting human health. Its precise modulation can prevent deadly infections and fight …
Advanced functional polymer materials
The research on advanced functional polymers is being driven by the fast-growing demand
for new functional materials that can be used in revolutionary technologies. Polymers can be …
for new functional materials that can be used in revolutionary technologies. Polymers can be …
Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonance signals
The rational design of theranostic nanoparticles exhibiting synergistic turn-on of therapeutic
potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient …
potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient …
Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy
S Zhai, X Hu, Y Hu, B Wu, D Xing - Biomaterials, 2017 - Elsevier
Undesired physiological instability of nanocarriers and premature drug leakage during
blood circulation result in compromised therapeutic efficacy and severe side effects, which …
blood circulation result in compromised therapeutic efficacy and severe side effects, which …