Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Splicing is a critical processing step during pre-mRNA maturation in eukaryotes. The correct
selection of splice sites during the early steps of spliceosome assembly is highly important …

The rational targeting of RNA with small molecules is hampered by our still limited
understanding of RNA structural and dynamic properties. Most in silico tools for binding site …

Regulatory RNA elements fulfill functions such as translational regulation, control of
transcript levels, and regulation of viral genome replication. Trans-acting factors (ie, RNA …

RNA recognition motifs (RRMs) play a pivotal role in RNA metabolism and the regulation of
gene expression. Owing to their plasticity and fuzziness, targeting RRM/RNA interfaces with …

RBM45 is an RNA-binding protein with roles in neural development by regulating RNA
splicing. Its dysfunction and aggregation are associated with neurodegenerative diseases …

Background The oncogenic protein HOXA9 plays a critical role in leukemia transformation
and maintenance, and its aberrant expression is a hallmark of most aggressive acute …

The RNA recognition motif (RRM) is a conserved and ubiquitous RNA-binding domain that
plays essential roles in mRNA splicing, polyadenylation, transport, and stability. RRM …

Targeting and manipulating endogenous RNAs in a sequence-specific manner is essential
for both understanding RNA biology and developing RNA-targeting therapeutics. RNA …

Abstract RNA binding motif 5 (RBM5) is a tumor suppressor in cancer but its role in the brain
is unclear. We used conditional gene knockout (KO) mice to test if RBM5 inhibition in the …