On the road to fight cancer: The potential of G-quadruplex ligands as novel therapeutic agents
I Alessandrini, M Recagni, N Zaffaroni… - International journal of …, 2021 - mdpi.com
Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …
within the human genome. This evidence strongly suggests that these genomic regions …
[HTML][HTML] Major achievements in the design of quadruplex-interactive small molecules
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …
acids have great potential as selective drugs or as tools in drug target discovery programs …
The hide-and-seek game of the oncogenic Epstein-Barr virus-encoded EBNA1 protein with the immune system: An RNA G-quadruplex tale
VT Dinh, N Loaëc, A Quillévéré, R Le Sénéchal… - Biochimie, 2023 - Elsevier
Abstract The Epstein-Barr virus (EBV) is the first oncogenic virus described in human. EBV
infects more than 90% of the human population worldwide, but most EBV infections are …
infects more than 90% of the human population worldwide, but most EBV infections are …
Role of chromatin damage and chromatin trapping of FACT in mediating the anticancer cytotoxicity of DNA-binding small-molecule drugs
E Nesher, A Safina, I Aljahdali, S Portwood, ES Wang… - Cancer research, 2018 - AACR
Precisely how DNA-targeting chemotherapeutic drugs trigger cancer cell death remains
unclear, as it is difficult to separate direct DNA damage from other effects in cells. Recent …
unclear, as it is difficult to separate direct DNA damage from other effects in cells. Recent …
G-quadruplex binding ligands: from naturally occurring to rationally designed molecules
T Vy Thi Le, S Han, J Chae… - Current pharmaceutical …, 2012 - ingentaconnect.com
Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …
Visualizing the quadruplex: from fluorescent ligands to light-up probes
Detection of quadruplex structures by visual methods is a major challenge of the quadruplex
nucleic acid research area. Consequently, considerable efforts are under way for the …
nucleic acid research area. Consequently, considerable efforts are under way for the …
ssDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival
Effective treatment of glioblastoma remains a daunting challenge. One of the major hurdles
in the development of therapeutics is their inability to cross the blood-brain tumor barrier …
in the development of therapeutics is their inability to cross the blood-brain tumor barrier …
Insights into the mechanism of binding of doxorubicin and a chlorin compound with 22-mer c-Myc G quadruplex
Background The interaction of small molecules with G quadruplexes is in focus due to its
role in molecular recognition and therapeutic drug design. Stabilization of G-quadruplex …
role in molecular recognition and therapeutic drug design. Stabilization of G-quadruplex …
Functional‐DNA‐Driven Dynamic Nanoconstructs for Biomolecule Capture and Drug Delivery
The discovery of sequence‐specific hybridization has allowed the development of DNA
nanotechnology, which is divided into two categories: 1) structural DNA nanotechnology …
nanotechnology, which is divided into two categories: 1) structural DNA nanotechnology …
Molecular rec § ognition of telomere DNA sequence by 2, 6 anthraquinone derivatives leads to thermal stabilization and induces apoptosis in cancer cells
According to current research, anti-cancer anthraquinones impact telomere disruption and
may interact with G-quadruplex DNA that triggers signaling to apoptosis. The present study …
may interact with G-quadruplex DNA that triggers signaling to apoptosis. The present study …