Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

Developmental stages in multicellular organisms proceed according to a temporally and
spatially precise pattern of gene expression. It has become evident that changes within the …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

The basic element for chromosome inheritance, the centromere, is epigenetically
determined in mammals. The prime candidate for specifying centromere identity is the array …

The Forkhead box m1 (Foxm1) gene is critical for G1/S transition and essential for mitotic
progression. However, the transcriptional mechanisms downstream of FoxM1 that control …

Centromeres direct chromosomal inheritance by nucleating assembly of the kinetochore, a
large multiprotein complex required for microtubule attachment during mitosis. Centromere …

Histones are subject to numerous post-translational modifications. Some of these
'epigenetic'marks recruit proteins that modulate chromatin structure. For example …

Centromeres are chromosomal elements that are both necessary and sufficient for
chromosome segregation. However, the puzzlingly broad range in centromere complexity …

Forkhead transcription factors are intimately involved in the regulation of organismal
development, cell differentiation and proliferation. Here we review the current knowledge of …

Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …