Medicinal attributes of 1, 2, 3-triazoles: Current developments

D Dheer, V Singh, R Shankar - Bioorganic Chemistry, 2017 - Elsevier
Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Triazole derivatives and their antiplasmodial and antimalarial activities

XM Chu, C Wang, WL Wang, LL Liang, W Liu… - European journal of …, 2019 - Elsevier
Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most
prevalent parasite Plasmodium falciparum, represents one of the most devastating and …

Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review

HL Qin, ZW Zhang, R Lekkala, H Alsulami… - European journal of …, 2020 - Elsevier
Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1, 2, 3-triazoles

S Kumar, B Sharma, V Mehra, V Kumar - European Journal of Medicinal …, 2021 - Elsevier
The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

Current development of 1, 2, 3-triazole derived potential antimalarial scaffolds: Structure activity relationship (SAR) and bioactive compounds

SMA Rahman, JS Bhatti, S Thareja, V Monga - European Journal of …, 2023 - Elsevier
Malaria is among one of the most devastating and deadliest parasitic disease in the world
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …

Quinoline-based hybrid compounds with antimalarial activity

X Nqoro, N Tobeka, BA Aderibigbe - Molecules, 2017 - mdpi.com
The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

Ferrocene-appended pharmacophores: An exciting approach for modulating the biological potential of organic scaffolds

A Singh, I Lumb, V Mehra, V Kumar - Dalton transactions, 2019 - pubs.rsc.org
Two exemplary contributions of organometallics in medicinal chemistry, ferroquine and
ferrocifen, which exhibit excellent anti-plasmodial and anti-cancer activities, respectively …

A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective

J Wang, F Gong, T Liang, Z Xie, Y Yang, C Cao… - European Journal of …, 2021 - Elsevier
Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

Ferrocene derivatives as anti-infective agents

BS Ludwig, JDG Correia, FE Kühn - Coordination Chemistry Reviews, 2019 - Elsevier
Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Perspectives of medicinally privileged chalcone based metal coordination compounds for biomedical applications

DK Mahapatra, SK Bharti, V Asati, SK Singh - European journal of …, 2019 - Elsevier
Recent clinical reports have highlighted the increasing occurrence of drug resistance of
known therapeutics. Particularly, antibiotic resistant microorganisms and multidrug …