Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

Microtubules (MTs) play a fundamental role in many vital processes such as cell division
and neuronal activity. They are key structural and functional elements in axons, supporting …

Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

Microtubules are dynamic assemblies of αβ‐tubulin heterodimers and have been
recognized as highly attractive targets for cancer chemotherapy. A broad range of agents …

Unsatisfactory outcomes for relapsed/refractory lymphoma patients prompt continuing efforts
to develop new therapeutic strategies. Our previous studies on pyrrole-based anti …

Small molecule drugs that target microtubules (MTs), many of them natural products, have
long been important tools in the MT field. Indeed, tubulin (Tb) was discovered, in part, as the …

Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated
α-tubulin. Despite the indispensable role of TTL in cell and organism development, its …

The unique characteristics of the tumor vasculature offer the possibility to selectively target
tumor growth and vascularization using tubulin-destabilizing agents. Evidence accumulated …