Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Chromosome 17q12-21 remains the most highly replicated and significant asthma locus.
Genotypes in the core region defined by the first genome-wide association study correlate …

Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

Asthma is a chronic disease of the airways characterized by inflammation, tightened
muscles, and thickened airway walls leading to symptoms such as shortness of breath, chest …

Chromosome 17q21 contains a cluster of genes including ORMDL3 and GSDMB, which
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …

Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants
in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular …

The bronchial epithelium is continuously exposed to a multitude of noxious challenges in
inhaled air. Cellular contact with most damaging agents is reduced by the action of the …

Risk for childhood asthma is conferred by alleles within the 17q21 locus affecting ORMDL
sphingolipid biosynthesis regulator 3 (ORMDL3) expression. ORMDL3 inhibits sphingolipid …

There is a strong genetic component to asthma, and numerous genome-wide association
studies have identified ORM1 (yeast)–like protein 3 (ORMDL3) as a gene associated with …

Introduction: The complex genetic diversity among human populations results from an
assortment of factors acting at various sequential levels, including mutations, population …