The cell surface is the platform for presentation of biochemical signals that are required for
intercellular communication. Their profile necessarily needs to be responsive to internal and …

NGLY1/Ngly1 is a cytosolic peptide: N-glycanase, ie. de-N-glycosylating enzyme acting on
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …

Oligosaccharyltransferase (OST) is a multi-span membrane protein complex that catalyzes
the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of …

The cytoplasmic peptide: N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme
that is highly conserved among eukaryotes. It was recently reported that subjects harboring …

Proteins are frequently modified by complex carbohydrates (glycans) that play central roles
in maintaining the structural and functional integrity of cells and tissues in humans and lower …

Background: Dolichyl-diphosphooligosaccharide–protein glycosyltransferase non-catalytic
subunit (DDOST) is an important enzyme in the process of high-mannose oligosaccharide …

Desialylation is a pivotal part of sialic acid metabolism, which initiates the catabolism of
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …

The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular
machineries generating considerably heterogeneous vesicle populations, including …

N-glycans on glycoproteins serve as one of the most important co-and post-translational
modifications of proteins, and it has been well established that they play pivotal roles in …

The endoplasmic reticulum (ER) is equipped with multiple quality control systems (QCS) that
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …