The sugar code: Why glycans are so important
HJ Gabius - Biosystems, 2018 - Elsevier
The cell surface is the platform for presentation of biochemical signals that are required for
intercellular communication. Their profile necessarily needs to be responsive to internal and …
intercellular communication. Their profile necessarily needs to be responsive to internal and …
The cytoplasmic peptide: N-glycanase (NGLY1)—Structure, expression and cellular functions
T Suzuki, C Huang, H Fujihira - Gene, 2016 - Elsevier
NGLY1/Ngly1 is a cytosolic peptide: N-glycanase, ie. de-N-glycosylating enzyme acting on
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …
[HTML][HTML] Oligosaccharyltransferase: a gatekeeper of health and tumor progression
Y Harada, Y Ohkawa, Y Kizuka… - International journal of …, 2019 - mdpi.com
Oligosaccharyltransferase (OST) is a multi-span membrane protein complex that catalyzes
the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of …
the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of …
[HTML][HTML] Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene
H Fujihira, Y Masahara-Negishi, M Tamura… - PLoS …, 2017 - journals.plos.org
The cytoplasmic peptide: N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme
that is highly conserved among eukaryotes. It was recently reported that subjects harboring …
that is highly conserved among eukaryotes. It was recently reported that subjects harboring …
Emerging roles of protein mannosylation in inflammation and infection
Proteins are frequently modified by complex carbohydrates (glycans) that play central roles
in maintaining the structural and functional integrity of cells and tissues in humans and lower …
in maintaining the structural and functional integrity of cells and tissues in humans and lower …
[HTML][HTML] Prognostic biomarker DDOST and its correlation with immune infiltrates in hepatocellular carcinoma
C Zhu, H Xiao, X Jiang, R Tong, J Guan - Frontiers in Genetics, 2022 - frontiersin.org
Background: Dolichyl-diphosphooligosaccharide–protein glycosyltransferase non-catalytic
subunit (DDOST) is an important enzyme in the process of high-mannose oligosaccharide …
subunit (DDOST) is an important enzyme in the process of high-mannose oligosaccharide …
Desialylation in physiological and pathological processes: New target for diagnostic and therapeutic development
M Wei, PG Wang - Progress in Molecular Biology and Translational …, 2019 - Elsevier
Desialylation is a pivotal part of sialic acid metabolism, which initiates the catabolism of
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …
[HTML][HTML] Glycometabolic regulation of the biogenesis of small extracellular vesicles
Y Harada, K Nakajima, T Suzuki, T Fukushige, K Kondo… - Cell Reports, 2020 - cell.com
The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular
machineries generating considerably heterogeneous vesicle populations, including …
machineries generating considerably heterogeneous vesicle populations, including …
Catabolism of N-glycoproteins in mammalian cells: Molecular mechanisms and genetic disorders related to the processes
T Suzuki - Molecular aspects of medicine, 2016 - Elsevier
N-glycans on glycoproteins serve as one of the most important co-and post-translational
modifications of proteins, and it has been well established that they play pivotal roles in …
modifications of proteins, and it has been well established that they play pivotal roles in …
Glycan quality control in and out of the endoplasmic reticulum of mammalian cells
Y Harada, Y Ohkawa, K Maeda… - The FEBS Journal, 2022 - Wiley Online Library
The endoplasmic reticulum (ER) is equipped with multiple quality control systems (QCS) that
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …