The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Amide bond construction has garnered significant interest in recent decades due to amides
being one of the most prevalent functional groups among bioactive molecules. Out of the …

Accessible drug modalities have continued to increase in number in recent years. Peptides
play a central role as pharmaceuticals and biomaterials in these new drug modalities …

We report the catalytic direct peptide bond formations via dehydrative condensation of β-
hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides …

A metal-, base-, and additive-free amide bond formation reaction was developed under an
organic photoredox catalyst. This green approach showed excellent functional selectivity …

Polyamides with various functional side groups were synthesized via Passerini reaction in a
one-pot approach. The polymerization conditions and kinetics as well as the resulting …

A remarkable visible-light-promoted photoredox catalytic methodology involved with amines
and eco-friendly potassium thioacids for amide formation was uncovered. This approach can …

The construction of peptidic amide bonds has become a daily laboratory practice by virtue of
well-established 'coupling reagents'. Nonetheless, inherent limitations connected to these …

N-Acylated amines are ubiquitous in nature. Selective N-acylation at neutral conditions
remains a key area of interest. Here we are reporting the copper sulfate-mediated highly …

Chemical synthesis of peptides and proteins has evolved into an indispensable tool for
chemical biology. Peptide ligation is a straightforward technique for joining two short peptide …