The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Molecular dynamics simulations have become a popular and powerful technique to study
lipids and membrane proteins. We present some general questions and issues that should …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

The concentration of cholesterol in cell membranes affects membrane fluidity and thickness,
and might regulate different processes such as the formation of lipid rafts. Since interpreting …

Molecular dynamics (MD) simulations provide a valuable approach to the dynamics,
structure, and stability of membrane–protein systems. Coarse-grained (CG) models, in which …

Interactions of lipids are central to the folding and stability of membrane proteins. Coarse-
grained molecular dynamics simulations have been used to reveal the mechanisms of self …

Studies of ion channels have for long been dominated by the animalcentric, if not
anthropocentric, view of physiology. The structures and activities of ion channels had …

Integral membrane proteins are embedded in a watersolvated lipid bilayer that presents
contrasting features in an anisotropic, chemically heterogeneous environment. A …

The MotA and MotB proteins of Escherichia coli serve two functions. The MotA4MotB2
complex attaches to the cell wall via MotB to form the stator of the flagellar motor. The …

Prestin is a high-density motor protein in the outer hair cells (OHCs), whose conformational
response to acoustic signals alters the shape of the cell, thereby playing a major role in …