N-myristoylation is the attachment of a 14-carbon fatty acid, myristate, onto the N-terminal
glycine residue of target proteins, catalysed by N-myristoyltransferase (NMT), a ubiquitous …

Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …

The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human …

Malaria is an infectious disease caused by parasites of the genus Plasmodium, which leads
to approximately one million deaths per annum worldwide. Chemical validation of new …

N-terminal N-myristoylation is a lipid anchor modification of eukaryotic and viral proteins
targeting them to membrane locations, thus changing the cellular function of modified …

N-Myristoyl transferase-mediated labelling using a substrate modified with an azide or
alkyne tag is described as an efficient and site-selective method for the introduction of a …

To accelerate progress in the development of therapeutics for protozoan parasitic diseases,
we are studying enzymes active in co-and post-translational protein modification that are …

Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the
treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to …

Plasmodium falciparum, the causative agent of malaria, relies on a sophisticated protein
secretion system for host cell invasion and transformation. Although the parasite displays a …

Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …