Human cortex transcriptomic studies have revealed a hierarchical organization of γ-
aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of …

G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …

The left temporal lobe is an integral part of the language system and its cortical structure and
function associate with general intelligence. However, whether cortical laminar architecture …

GWAS have identified numerous genes associated with human cognition but their cell type
expression profiles in the human brain are unknown. These genes overlap with human …

Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent
findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest …

Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit
enormous diversity in their expression patterns, sequence homology, pharmacology …

Objective. In partial epilepsies, interictal epileptiform discharges (IEDs) are paroxysmal
events observed in epileptogenic zone (EZ) and non-epileptogenic zone (NEZ). IEDs' …

Background Epilepsy is a paroxysmal disorder of the brain, caused by an imbalance of
neuronal excitation and inhibition. Glutamate is the most important excitatory …

Synapses in the cerebral cortex constantly change and this dynamic property regulated by
the action of neuromodulators such as dopamine (DA), is essential for reward learning and …

Background: Slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep
reflects synaptic potentiation during preceding wakefulness. Epileptic activity may induce …