The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …

Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Introduction: Adverse childhood experiences (ACE) such as sexual and physical abuse or
neglect are frequent in childhood and constitute a massive stressor with long-lasting …

The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …

Objective: Black Americans in the United States are disproportionately exposed to childhood
adversity compared with White Americans. Such disparities may contribute to race-related …

Adolescenceâ€" beginning with the onset of puberty and ending in the mid-20sâ€" is a
critical period of development during which key areas of the brain mature and develop …

Maltreatment-related childhood adversity is the leading preventable risk factor for mental
illness and substance abuse. Although the association between maltreatment and …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Despite long-standing interest in the influence of adverse early experiences on mental
health, systematic scientific inquiry into childhood adversity and developmental outcomes …