Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather
antigens and danger signals derived from microbes and tissue. Subsequently, DCs integrate …

The interplay between cellular stress and immune response can be variable and sometimes
contradictory. The mechanisms by which stress-activated pathways regulate the …

Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …

CD38 is a multifunctional protein widely expressed in cells from the immune system and as
a soluble form in biological fluids. CD38 expression is up-regulated by an array of …

ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis.
Their anti-atherogenic potential has been attributed to their role in the inhibition of …

Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …

Excess dietary cholesterol intake and the dysregulation of cholesterol metabolism are
associated with the pathogenesis and progression of nonalcoholic fatty liver disease …

Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that act as
biological sensors and use a combination of mechanisms to modulate positively and …

The liver X receptors α and β (LXR α and LXR β) are oxysterol-activated transcription factors
that coordinately regulate gene expression that is important for cholesterol and fatty acid …