Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …

Bone tissue renewal can be outlined as a complicated mechanism centered on the
interaction between osteogenic and angiogenic events capable of leading to bone formation …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

The p38 mitogen-activated protein kinase (MAPK) signaling pathway can be activated in
response to a wide range of extracellular signals. As a consequence, it can generate many …

Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a
process in which they are embedded in an osteoid. We previously showed that nutrient …

In extant species, bone formation is restricted to vertebrate species. Sp7/Osterix is a key
transcriptional determinant of bone-secreting osteoblasts. We performed Sp7 chromatin …

Stem cells have received attention in various diseases, such as inflammatory, cancer, and
bone diseases. Mesenchymal stem cells (MSCs) are multipotent stem cells that are critical …

Inducing the osteogenic differentiation from bone marrow stromal cells (BMSCs) might be a
potent strategy for treating bone loss and nonunion during fracture and improving fracture …

Osteoporosis is a systemic skeletal disorder affecting over 200 million people worldwide and
contributes dramatically to global healthcare costs. Available anti-osteoporotic drug …