Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia
Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a
central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia …
central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia …
The mechanisms of ferroptosis and its role in alzheimer's disease
H Ma, Y Dong, Y Chu, Y Guo, L Li - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) accounts for two-thirds of all dementia cases, affecting 50 million
people worldwide. Only four of the more than 100 AD drugs developed thus far have …
people worldwide. Only four of the more than 100 AD drugs developed thus far have …
Tau oligomers neurotoxicity
G Niewiadomska, W Niewiadomski, M Steczkowska… - Life, 2021 - mdpi.com
Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …
Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …
worldwide. Intracellular transduction pathways that end in the activation of specific …
The complex mechanisms by which neurons die following DNA damage in neurodegenerative diseases
Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …
Caspases in Alzheimer's disease: mechanism of activation, role, and potential treatment
P Wójcik, MK Jastrzębski, A Zięba, D Matosiuk… - Molecular …, 2024 - Springer
With the aging of the population, treatment of conditions emerging in old age, such as
neurodegenerative disorders, has become a major medical challenge. Of these, Alzheimer's …
neurodegenerative disorders, has become a major medical challenge. Of these, Alzheimer's …
Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease
Ubiquitin-modified tau aggregates are abundantly found in human brains diagnosed with
Alzheimer's disease (AD) and other tauopathies. Soluble tau oligomers (TauO) are the most …
Alzheimer's disease (AD) and other tauopathies. Soluble tau oligomers (TauO) are the most …
Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies
G Karmon, S Sragovich, G Hacohen-Kleiman… - Biological …, 2022 - Elsevier
Background ADNP is essential for embryonic development. As such, de novo ADNP
mutations lead to an intractable autism/intellectual disability syndrome requiring …
mutations lead to an intractable autism/intellectual disability syndrome requiring …