[HTML][HTML] Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of …

A Grylls, K Seidler, J Neil - Biomedicine & Pharmacotherapy, 2021 - Elsevier
High blood pressure (BP) presents a significant public health challenge. Recent findings
suggest that altered microbiota can exert a hypertensive effect on the host. One of the …

Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions

L Pérez, N Muñoz-Durango, CA Riedel… - Cytokine & growth factor …, 2017 - Elsevier
During the last decade, the endothelial-to-mesenchymal transition (EndMT) process has
attracted considerable attention due to associations with the onset of certain diseases, such …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

[HTML][HTML] TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis

R Zhou, Y Chen, S Li, X Wei, W Hu, J Ding, W Fu… - Redox biology, 2022 - Elsevier
A role for ferroptosis in articular cartilage destruction associated with rheumatoid arthritis
(RA) has not been identified. We previously reported transient receptor potential melastatin …

Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome

T Romacho, I Valencia, M Ramos-González… - Scientific reports, 2020 - nature.com
Abstract Visfatin/extracellular-nicotinamide-phosphoribosyltranferase-(eNampt) is a
multifaceted adipokine enhanced in type-2-diabetes and obesity. Visfatin/eNampt cause in …

TRPM channels in human diseases

I Jimenez, Y Prado, F Marchant, C Otero, F Eltit… - Cells, 2020 - mdpi.com
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …

Lipopolysaccharides from Porphyromonas endodontalis and Porphyromonas gingivalis promote angiogenesis via Toll‐like‐receptors 2 and 4 pathways in vitro

A Fernández, D Herrera, A Hoare… - International …, 2023 - Wiley Online Library
Aim Angiogenesis contributes to the development of apical periodontitis, periodontitis, and
other oral pathologies; however, it remains unclear how this process is triggered. The aim …

Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential

K Takov, Z He, HE Johnston, JF Timms… - Basic Research in …, 2020 - Springer
Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in
models of myocardial infarction which may be mediated by secreted small extracellular …

Different concentrations of lipopolysaccharide regulate barrier function through the PI3K/Akt signalling pathway in human pulmonary microvascular endothelial cells

X Zheng, W Zhang, X Hu - Scientific reports, 2018 - nature.com
Lipopolysaccharide (LPS) can lead to vascular endothelial barrier dysfunction, which often
results in acute lung injury and acute respiratory distress syndrome. However, the effects of …

LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs

X Chen, D Song - Bioscience Reports, 2020 - portlandpress.com
Sepsis is a systemic inflammatory response syndrome caused by infection.
Lipopolysaccharide (LPS) has been reported to induce inflammatory responses, and long …