There has long been evidence that hepatitis C can lead to persistent infection in a high
proportion of infected individuals, and can progress to chronic liver disease, cirrhosis and …

Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is
attributed to excess deposition of extracellular matrix components including collagen …

Hepatitis C virus (HCV) infection is a leading cause of cirrhosis, hepatocellular carcinoma,
and liver transplantation. A better understanding of HCV disease progression and the …

Tissue fibrosis (scarring) is a leading cause of morbidity and mortality. Current treatments for
fibrotic disorders, such as idiopathic pulmonary fibrosis, hepatic fibrosis and systemic …

Acute inflammation is a recognised part of normal wound healing. However, when
inflammation fails to resolve and a chronic inflammatory response is established this …

Liver fibrosis is the main predictor of the progression of chronic hepatitis C, and its
assessment by liver biopsy (LB) can help determine therapy. However, biopsy is an invasive …

More than 400 million people worldwide are chronically infected by the hepatitis B virus. The
virus is responsible for more than 300000 cases of liver cancer every year and for similar …

Fundamental cellular operations, including DNA synthesis and the generation of ATP,
require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron …

It is estimated that viral infections contribute to 15–20% of all human cancers. As obligatory
intracellular parasites, viruses encode proteins that reprogram host cellular signaling …

Infection and chronic inflammation are proposed to contribute to carcinogenesis through
inflammation-related mechanisms. Infection with hepatitis C virus, Helicobacter pylori and …