Connexins: synthesis, post-translational modifications, and trafficking in health and disease
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …
direct intercellular communication, a critical feature for the development, function, and …
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2,
FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and …
FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and …
RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Sex determination of the gonads begins with fate specification of gonadal supporting cells
into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification …
into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification …
Estrogen, estrogen-like molecules and autoimmune diseases
J Merrheim, J Villegas, J Van Wassenhove… - Autoimmunity …, 2020 - Elsevier
In western countries, the slope of autoimmune disease (AD) incidence is increasing and
affects 5–8% of the population. Mainly prevalent in women, these pathologies are due to …
affects 5–8% of the population. Mainly prevalent in women, these pathologies are due to …
RUNX1‐dependent mechanisms in biological control and dysregulation in cancer
The RUNX1 transcription factor has recently been shown to be obligatory for normal
development. RUNX1 controls the expression of genes essential for proper development in …
development. RUNX1 controls the expression of genes essential for proper development in …
RUNX1 is regulated by androgen receptor to promote cancer stem markers and chemotherapy resistance in triple negative breast cancer
NB Fernández, SM Sosa, JT Roberts, MS Recouvreux… - Cells, 2023 - mdpi.com
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which no
effective targeted therapies are available. Growing evidence suggests that chemotherapy …
effective targeted therapies are available. Growing evidence suggests that chemotherapy …
Suppression of breast cancer stem cells and tumor growth by the RUNX1 transcription factor
D Hong, AJ Fritz, KH Finstad, MP Fitzgerald… - Molecular Cancer …, 2018 - AACR
Breast cancer remains the most common malignant disease in women worldwide. Despite
advances in detection and therapies, studies are still needed to understand the mechanisms …
advances in detection and therapies, studies are still needed to understand the mechanisms …
RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells
Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and
refractory to conventional therapies. Consequently BCSCs are implicated in tumor …
refractory to conventional therapies. Consequently BCSCs are implicated in tumor …
R‐spondin‐mediated WNT signaling potentiation in mammary and breast cancer development
The mammary gland is a secretory organ, which develops as a network of growing epithelial
ducts composed of luminal and basal cells that invade the surrounding adipose tissue …
ducts composed of luminal and basal cells that invade the surrounding adipose tissue …
RUNX1 as a novel molecular target for breast cancer
NS Ariffin - Clinical Breast Cancer, 2022 - Elsevier
RUNX1 has long known for its role in hematopoiesis until recently it is implicated in human
breast cancer pathogenesis. This has drawn attention in research as elevated expression of …
breast cancer pathogenesis. This has drawn attention in research as elevated expression of …