Hierarchical agglomerative clustering (HAC) with Ward's linkage has been widely used
since its introduction by Ward (Journal of the American Statistical Association, 58 (301), 236 …

The three-dimensional organization of chromatin plays a crucial role in gene regulation and
cellular processes like deoxyribonucleic acid (DNA) transcription, replication and repair. Hi …

The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …

Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-
ranging domains encompassing multiple transcriptional units, including heritability loci for …

Abstract Background Topologically associating domains (TADs) are locally highly-
interacting genome regions, which also play a critical role in regulating gene expression in …

Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the leading
cause of dementia. Early diagnosis is critical for patients to benefit from potential intervention …

Topologically associating domains (TADs) are local chromatin interaction domains, which
have been shown to play an important role in gene expression regulation. TADs were …

Fatty acid composition in milk is not only reflective of nutritional quality but also potentially
predictive of other attributes (eg including the cow's energy balance and its relative output of …

This article addresses a common type of data encountered in genomic studies, where a
signal along a linear chromosome exhibits a hierarchical organization. We propose a novel …