Clostridium difficile colitis: pathogenesis and host defence

MC Abt, PT McKenney, EG Pamer - Nature Reviews Microbiology, 2016 - nature.com
Clostridium difficile is a major cause of intestinal infection and diarrhoea in individuals
following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that …

The role of toxins in Clostridium difficile infection

R Chandrasekaran, DB Lacy - FEMS microbiology reviews, 2017 - academic.oup.com
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …

[HTML][HTML] An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

J Chen, K Wright, JM Davis, P Jeraldo, EV Marietta… - Genome medicine, 2016 - Springer
Background The adaptive immune response in rheumatoid arthritis (RA) is influenced by an
interaction between host genetics and environment, particularly the host microbiome …

Yeasts as probiotics: Mechanisms, outcomes, and future potential

S Sen, TJ Mansell - Fungal Genetics and Biology, 2020 - Elsevier
The presence of commensal fungal species in the human gut indicates that organisms from
this kingdom have the potential to benefit the host as well. Saccharomyces boulardii, a yeast …

[HTML][HTML] Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance

RP Barcelos, FD Lima, NR Carvalho, G Bresciani… - Nutrition Research, 2020 - Elsevier
Caffeine, a xanthine alkaloid compound, is consumed widely and daily by humans, as it is
present in several regular beverages such as tea, coffee, soda beverages, and some drugs …

The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?

J Bien, V Palagani, P Bozko - Therapeutic advances in …, 2013 - journals.sagepub.com
Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian
gastrointestinal tract. They display a symbiotic relationship with the host contributing to its …

Cytokines are markers of the Clostridium difficile-induced inflammatory response and predict disease severity

H Yu, K Chen, Y Sun, M Carter, KW Garey… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
The host immune response affects pathogen virulence in Clostridium difficile infection (CDI).
Thus, cytokine responses to CDI likely are associated with disease initiation and …

[HTML][HTML] NF-κB inducing kinase regulates intestinal immunity and homeostasis

B Wang, J Shen - Frontiers in Immunology, 2022 - frontiersin.org
Intestinal immunity and homeostasis are maintained through the regulation of cytokine
trafficking, microbiota, necrosis and apoptosis. Intestinal immunity and homeostasis …

[HTML][HTML] Akkermansia muciniphila Ameliorates Clostridioides difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites

Z Wu, Q Xu, S Gu, Y Chen, L Lv, B Zheng… - Frontiers in …, 2022 - frontiersin.org
Clostridioides difficile is a common cause of nosocomial infection. Antibiotic-induced
dysbiosis in the intestinal microbiota is a core cause of C. difficile infection (CDI) …

Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile

H Chandra, KK Sharma, OH Tuovinen, X Sun… - Gut …, 2021 - Taylor & Francis
Pathobionts are opportunistic microbes that emerge as a result of perturbations in the
healthy microbiome due to complex interactions of various genetic, exposomal, microbial …