Emerging evidence for adapting radiotherapy to immunotherapy
L Galluzzi, MJ Aryankalayil, CN Coleman… - Nature reviews Clinical …, 2023 - nature.com
Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …
infrequently associated with durable objective responses when used as a standalone …
NK cells and solid tumors: therapeutic potential and persisting obstacles
L Tong, C Jiménez-Cortegana, AHM Tay, S Wickström… - Molecular cancer, 2022 - Springer
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …
Strategies to improve the antitumor effect of immunotherapy for hepatocellular carcinoma
R Xing, J Gao, Q Cui, Q Wang - Frontiers in immunology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC), one of the most fatal malignancies in the world, is usually
diagnosed in advanced stages due to late symptom manifestation with very limited …
diagnosed in advanced stages due to late symptom manifestation with very limited …
A metal–phenolic nanocoordinator launches radiotherapeutic cancer pyroptosis through an epigenetic mechanism
Radiotherapy, although clinically effective in immunoactivation, still cannot radio‐
functionalize tumor as a potent immunogenetic center. Given that newly found pyroptosis …
functionalize tumor as a potent immunogenetic center. Given that newly found pyroptosis …
Ruthenium‐based metal–organic nanoradiosensitizers enhance radiotherapy by combining ROS generation and CO gas release
Q Dai, L Wang, E Ren, H Chen, X Gao… - Angewandte Chemie …, 2022 - Wiley Online Library
A lack of targeting accuracy and radiosensitivity severely limits clinical radiotherapy. In this
study, we developed a radiosensitizer comprised of Ru‐based metal–organic …
study, we developed a radiosensitizer comprised of Ru‐based metal–organic …
When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death
Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion
to prevent negative consequences for the tissue or the organism. Dysfunctional apoptosis is …
to prevent negative consequences for the tissue or the organism. Dysfunctional apoptosis is …
Precise Engineering of a Se/Te Nanochaperone for Reinvigorating Cancer Radio‐Immunotherapy
Y Chang, J Huang, S Shi, L Xu, H Lin… - Advanced …, 2023 - Wiley Online Library
Facilely synthesized nanoradiosensitizers with well‐controlled structure and
multifunctionality are greatly desired to address the challenges of cancer radiotherapy. In …
multifunctionality are greatly desired to address the challenges of cancer radiotherapy. In …
Engineered living materials for advanced diseases therapy
X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …
Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …
stressors, occupies a central position in the development of novel anticancer treatments …
Cancer cell metabolism and antitumour immunity
Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour
progression not only by providing cancer cells with increased proliferative potential and an …
progression not only by providing cancer cells with increased proliferative potential and an …