Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

The genesis of skeletal muscle during embryonic development and postnatal life serves as a
paradigm for stem and progenitor cell maintenance, lineage specification, and terminal …

Prenatal and postnatal myogenesis share many cellular and molecular aspects. Myogenic
regulatory factors are basic Helix-Loop-Helix transcription factors that indispensably …

Mice carrying null mutations in the myogenic regulatory factors Myf-5 or YyoD have
apparently normal skeletal muscle. To address whether these two factors functionally …

The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose
principal function is contraction. The fully differentiated or mature SMC proliferates at an …

We have isolated a cDNA clone encoding a novel helixloophdix (HLH) protein, Id. Id is
missing the basic region adjacent to the HLH domain that is essential for specific DNA …

The implantation of bone morphogenetic protein (BMP) into muscular tissues induces
ectopic bone formation at the site of implantation. To investigate the mechanism underlying …

MyoD is a master regulatory gene for myogenesis. Under the control of a retroviral long
terminal repeat, MyoD was expressed in a variety of differentiated cell types by using either …