Acute myeloid leukaemia

A Khwaja, M Bjorkholm, RE Gale, RL Levine… - Nature reviews Disease …, 2016 - nature.com
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …

Modern risk stratification of acute myeloid leukemia in 2023: integrating established and emerging prognostic factors

E Boscaro, I Urbino, FM Catania, G Arrigo, C Secreto… - Cancers, 2023 - mdpi.com
Simple Summary Several factors, both patient-and disease-related, are essential to
accurately estimate acute myeloid leukemia (AML) prognosis. The rapidly evolving field …

Characterization and prognostic features of secondary acute myeloid leukemia in a population‐based setting: A report from the S wedish A cute L eukemia R egistry

E Hulegårdh, C Nilsson, V Lazarevic… - American journal of …, 2015 - Wiley Online Library
Patients with secondary acute myeloid leukemia (AML) often escape inclusion in clinical
trials and thus, population‐based studies are crucial for its accurate characterization. In this …

Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care

H Döhner, A Dolnik, L Tang, JF Seymour, MD Minden… - Leukemia, 2018 - nature.com
Older patients with newly diagnosed acute myeloid leukemia (AML) in the phase 3 AZA-AML-
001 study were evaluated at entry for cytogenetic abnormalities, and a subgroup of patients …

Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology

DA Arber, MJ Borowitz, M Cessna… - … of pathology & …, 2017 - meridian.allenpress.com
Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

Incidence, survival, and risk factors for adults with acute myeloid leukemia not otherwise specified and acute myeloid leukemia with recurrent genetic abnormalities …

X Song, Y Peng, X Wang, Y Chen, L Jin, T Yang… - Acta …, 2018 - karger.com
Abstract Background/Aim: As the knowledgebase of acute myeloid leukemia (AML) has
grown, classification systems have moved to incorporate these new findings. Methods: We …

Improved survival of men 50 to 75 years old with acute myeloid leukemia over a 20-year period

G Juliusson, O Hagberg, VL Lazarevic… - Blood, The Journal …, 2019 - ashpublications.org
Acute myeloid leukemia (AML) is a devastating disease, globally causing 85 000 deaths per
year in 2016, a number predicted to double in 2040, with years of life lost estimated to be 2.6 …

Treatment, trial participation and survival in adult acute myeloid leukemia: a population-based study in the Netherlands, 1989–2012

AG Dinmohamed, O Visser, Y van Norden… - Leukemia, 2016 - nature.com
Large, comprehensive population-based studies in acute myeloid leukemia (AML) are
scarce. We conducted a nationwide population-based study on treatment, trial participation …

[HTML][HTML] DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and …

C Flotho, S Sommer, M Lübbert - Seminars in Cancer Biology, 2018 - Elsevier
Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder, typically of older adults,
which is characterized by ineffective hematopoiesis, peripheral blood cytopenias and risk of …

Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape

P Silva, M Neumann, MP Schroeder, S Vosberg… - Leukemia, 2017 - nature.com
1 Grimwade D, Ivey A, Huntly BJ. Molecular landscape of acute myeloid leukemia in
younger adults and its clinical relevance. Blood 2016; 127: 29–42. 2 Xie M, Lu C, Wang J …