Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

The blood plasma of numerous snake species naturally comprises endogenous
phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may …

Snakebite is a medical emergency in many parts of the world, particularly in the temperate
regions. According to 2007 World Health Organization (WHO) report, there are about 5 …

Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids
resulting in fatty acids and lysophospholipids and deconstructing the cell membrane. This …

In the present work, we describe the isolation and partial structural and biochemical
characterization of the first phospholipase A 2 inhibitor (γPLI) from Crotalus durissus …

The use of venom in predation exerts a corresponding selection pressure for the evolution of
venom resistance. One of the mechanisms related to venom resistance in animals …

It is of popular and scientific knowledge that toxins from snake venom (among them the
PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and …

Snakebite envenomation is a neglected condition that constitutes a public health problem in
tropical and subtropical countries, including Brazil. Interestingly, some animals are resistant …

Abstract Phospholipases A 2 (PLA 2 s) are associated with inflammatory response,
performing a complex process involving, specially, cytokines. The excess of pro …

Venomous and non-venomous snakes possess phospholipase A 2 (PLA 2) inhibitory
proteins (PLIs) in their blood serum. This study shows the expression and biochemical and …