[HTML][HTML] Genetic architecture of Alzheimer's disease
Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …
Genetic variants in mRNA untranslated regions
M Steri, ML Idda, MB Whalen… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants
associated with complex disease risk and regulating quantitative traits, thus exploiting an …
associated with complex disease risk and regulating quantitative traits, thus exploiting an …
Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and
public health strategies. Viral–host interactions can guide discovery of disease regulators …
public health strategies. Viral–host interactions can guide discovery of disease regulators …
Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis
Background Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder
affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic …
affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic …
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …
but associations between neurobiological mechanisms and macroscale connectomics …
PhenomeXcan: Mapping the genome to the phenome through the transcriptome
Large-scale genomic and transcriptomic initiatives offer unprecedented insight into complex
traits, but clinical translation remains limited by variant-level associations without biological …
traits, but clinical translation remains limited by variant-level associations without biological …
Convergence between biological, behavioural and genetic determinants of obesity
S Ghosh, C Bouchard - Nature Reviews Genetics, 2017 - nature.com
Multiple biological, behavioural and genetic determinants or correlates of obesity have been
identified to date. Genome-wide association studies (GWAS) have contributed to the …
identified to date. Genome-wide association studies (GWAS) have contributed to the …
Biophysical and mechanistic models for disease-causing protein variants
The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In
medicine, genome sequencing has revealed millions of missense variants that change …
medicine, genome sequencing has revealed millions of missense variants that change …
Phenotype prediction and genome-wide association study using deep convolutional neural network of soybean
Genomic selection uses single-nucleotide polymorphisms (SNPs) to predict quantitative
phenotypes for enhancing traits in breeding populations and has been widely used to …
phenotypes for enhancing traits in breeding populations and has been widely used to …
An integrative approach for building personalized gene regulatory networks for precision medicine
Only a small fraction of patients respond to the drug prescribed to treat their disease, which
means that most are at risk of unnecessary exposure to side effects through ineffective …
means that most are at risk of unnecessary exposure to side effects through ineffective …