Bioactive glasses for in situ tissue regeneration
LL Hench, ID Xynos, JM Polak - Journal of Biomaterials Science …, 2004 - Taylor & Francis
Historically the function of biomaterials has been to replace diseased or damaged tissues.
Recent findings show that controlled release of the ionic dissolution products of bioactive …
Recent findings show that controlled release of the ionic dissolution products of bioactive …
Genetics of melanoma predisposition
NK Hayward - Oncogene, 2003 - nature.com
Predisposition to melanoma is genetically heterogeneous. Two high penetrance
susceptibility genes, CDKN2A and CDK4, have so far been identified and mapping is …
susceptibility genes, CDKN2A and CDK4, have so far been identified and mapping is …
Biomarker analyses of response to cyclin-dependent kinase 4/6 inhibition and endocrine therapy in women with treatment-naïve metastatic breast cancer
RS Finn, Y Liu, Z Zhu, M Martin, HS Rugo, V Diéras… - Clinical Cancer …, 2020 - AACR
Purpose: Preclinical data identified the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor
palbociclib as synergistic with antiestrogens in inhibiting growth of hormone receptor …
palbociclib as synergistic with antiestrogens in inhibiting growth of hormone receptor …
Gene‐expression profiling of human osteoblasts following treatment with the ionic products of Bioglass® 45S5 dissolution
ID Xynos, AJ Edgar, LDK Buttery… - … Research: An Official …, 2001 - Wiley Online Library
The effect of the ionic products of Bioglass® 45S5 dissolution on the gene‐expression
profile of human osteoblasts was investigated by cDNA microarray analysis of 1,176 genes …
profile of human osteoblasts was investigated by cDNA microarray analysis of 1,176 genes …
Detection of exosomal miRNAs in the plasma of melanoma patients
SR Pfeffer, KF Grossmann, PB Cassidy… - Journal of clinical …, 2015 - mdpi.com
MicroRNAs (miRNAs) are a class of 22–25 nucleotide RNAs that control gene expression at
the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a …
the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a …
Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study
SR Alonso, P Ortiz, M Pollán, B Pérez-Gómez… - The American journal of …, 2004 - Elsevier
Cutaneous malignant melanoma remains the leading cause of skin cancer death in
industrialized countries. Clinical and histological variables that predict survival, such as …
industrialized countries. Clinical and histological variables that predict survival, such as …
BRAF Mutations in Metastatic Melanoma: A Possible Association with Clinical Outcome
R Kumar, S Angelini, K Czene, I Sauroja… - Clinical Cancer …, 2003 - AACR
Abstract Purpose: The RAS-RAF-mitogen-activated protein kinase pathways mediate the
cellular response to growth signals. In melanocytes, BRAF is involved in cAMP-dependent …
cellular response to growth signals. In melanocytes, BRAF is involved in cAMP-dependent …
Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis
BEG Rothberg, MB Bracken… - Journal of the national …, 2009 - academic.oup.com
In the clinical management of early-stage cutaneous melanoma, it is critical to determine
which patients are cured by surgery alone and which should be treated with adjuvant …
which patients are cured by surgery alone and which should be treated with adjuvant …
The role of cell cycle regulatory proteins in the pathogenesis of melanoma
W Li, A Sanki, RZ Karim, JF Thompson, C Soon Lee… - Pathology, 2006 - Taylor & Francis
The transformation of melanocytes to melanoma cells is characterised by abnormal
proliferation resulting from alterations in cell cycle regulatory mechanisms. This occurs …
proliferation resulting from alterations in cell cycle regulatory mechanisms. This occurs …
HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma
D Polsky, BC Bastian, C Hazan, K Melzer, J Pack… - Cancer research, 2001 - AACR
We investigated the role of alterations of HDM2, the human homologue of murine mdm2, in
the tumorigenesis and progression of cutaneous melanoma. A well-characterized cohort of …
the tumorigenesis and progression of cutaneous melanoma. A well-characterized cohort of …