Historically the function of biomaterials has been to replace diseased or damaged tissues.
Recent findings show that controlled release of the ionic dissolution products of bioactive …

Predisposition to melanoma is genetically heterogeneous. Two high penetrance
susceptibility genes, CDKN2A and CDK4, have so far been identified and mapping is …

Purpose: Preclinical data identified the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor
palbociclib as synergistic with antiestrogens in inhibiting growth of hormone receptor …

The effect of the ionic products of Bioglass® 45S5 dissolution on the gene‐expression
profile of human osteoblasts was investigated by cDNA microarray analysis of 1,176 genes …

MicroRNAs (miRNAs) are a class of 22–25 nucleotide RNAs that control gene expression at
the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a …

Cutaneous malignant melanoma remains the leading cause of skin cancer death in
industrialized countries. Clinical and histological variables that predict survival, such as …

Abstract Purpose: The RAS-RAF-mitogen-activated protein kinase pathways mediate the
cellular response to growth signals. In melanocytes, BRAF is involved in cAMP-dependent …

In the clinical management of early-stage cutaneous melanoma, it is critical to determine
which patients are cured by surgery alone and which should be treated with adjuvant …

The transformation of melanocytes to melanoma cells is characterised by abnormal
proliferation resulting from alterations in cell cycle regulatory mechanisms. This occurs …

We investigated the role of alterations of HDM2, the human homologue of murine mdm2, in
the tumorigenesis and progression of cutaneous melanoma. A well-characterized cohort of …