Although emerging data shed more light on the complex role of IL-18 in immune reactions,
they also pose more questions. Given the pleiotropic, complex, and at times paradoxic …

Allogeneic hematopoietic cell transplantation (HCT) has emerged as an important
therapeutic option for several malignant and nonmalignant diseases. In addition to …

Administration of exogenous interleukin-18 (IL-18) regulates experimental acute graft-versus-
host disease (GVHD) in a Fas-dependent manner when donor CD4+ T cells are required for …

BACKGROUND: Graft-versus-host disease is one of the major complications after allogeneic
bone marrow transplantation, but it is not easy to anticipate the onset. Cytokines released by …

Recent studies have suggested that Fas-mediated apoptosis is involved in the pathogenesis
of intestinal injury. In this study, we determined the role of Fas/Fas ligand (FasL) interactions …

Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide (LPS)-activated
macrophages or Kupffer cells. In addition, IL-18 is also produced by many different types of …

Graft-versus-host disease (GVHD) is a devastating complication of hematopoietic stem cell
transplantation (HSCT), and is characterized by systemic inflammation and tissue damage in …

Summary Interleukin‐18 (IL‐18), a proinflammatory cytokine, is elevated in patients with
acute graft‐versus‐host disease (aGVHD). IL‐18 induces Th1 differentiation and cytotoxic T …

Interleukin (IL)-18 stimulates T helper 1 (Th1) and Th2-mediated immune responses, and
has been shown to modulate acute graft-versus-host disease (aGVHD). It is still unknown …

Interleukin (IL) 18 is a potent pro‐inflammatory Th1 cytokine that exerts pleiotropic effector
functions in both innate and acquired immune responses. Increased IL‐18 production during …