Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can
lead to genomic change or cell death. Organisms have developed several pathways and …

▪ Abstract Mismatch repair (MMR) systems play a central role in promoting genetic stability
by repairing DNA replication errors, inhibiting recombination between non-identical DNA …

DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …

▪ Abstract DNA mismatch repair (MMR) guards the integrity of the genome in virtually all
cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …

The secreted protein Sonic hedgehog (Shh) exerts many of its patterning effects through a
combination of short-and long-range signalling,,. Three distinct mechanisms, which are not …

This paper reports reconstitution of 5′-nick-directed mismatch repair using purified human
proteins. The reconstituted system includes MutSα or MutSβ, MutLα, RPA, EXO1, HMGB1 …

When a telomere becomes unprotected or if only one end of a chromosomal double-strand
break succeeds in recombining with a template sequence, DNA can be repaired by a …

The Escherichia coli gene recQ was identified as a RecF recombination pathway gene 1.
The gene SGS1, encoding the only RecQ-like DNA helicase in Saccharomyces cerevisiae …

For> 20 years, the enigmatic behavior of plant mitochondrial genomes has been well
described but not well understood. Chimeric genes appear, and occasionally are …