Testosterone replacement therapy and cardiovascular risk

T Gagliano-Jucá, S Basaria - Nature Reviews Cardiology, 2019 - nature.com
Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

Late‐onset hypogonadism: Reductio ad absurdum of the cardiovascular risk‐benefit of testosterone replacement therapy

F Sesti, R Pofi, M Minnetti, M Tenuta, D Gianfrilli… - …, 2020 - Wiley Online Library
Background Low testosterone (T) level is considered a marker of poor cardiovascular health.
Ten years ago, the Testosterone in Older Men with Mobility Limitations (TOM) trial was …

Mechanisms of sex and age differences in ventricular repolarization in humans

J Vicente, L Johannesen, L Galeotti, DG Strauss - American heart journal, 2014 - Elsevier
Introduction Corrected QT interval (QTc) is shorter in postpubertal men than in women;
however, QTc lengthens as men age and testosterone levels decrease. Animal studies have …

Androgen deprivation therapy is associated with prolongation of QTc interval in men with prostate cancer

T Gagliano-Jucá, TG Travison… - Journal of the …, 2018 - academic.oup.com
Context Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with
increased cardiovascular mortality and sudden cardiac death, with some events occurring …

Standard values and characteristics of electrocardiographic findings in children and adolescents

M Yoshinaga, M Iwamoto, H Horigome… - Circulation …, 2018 - jstage.jst.go.jp
Background: Reference values and the characteristics of the electrocardiographic (ECG)
findings using a large number of subjects are lacking for children and adolescents. Methods …

Effects of testosterone replacement on electrocardiographic parameters in men: findings from two randomized trials

T Gagliano-Juca, TB İçli, KM Pencina… - The Journal of …, 2017 - academic.oup.com
Context: Endogenous testosterone levels have been negatively associated with QTc interval
in small case series; the effects of testosterone therapy on electrocardiographic parameters …

Sex hormone levels in patients with sudden cardiac arrest

K Narayanan, R Havmoeller, K Reinier, K Jerger… - Heart Rhythm, 2014 - Elsevier
Background Sex hormones are known to have significant effects on the pathophysiology of
cardiovascular disease. Objective The purpose of this study was to study the association …

Early repolarization in athletes: a review

P Aagaard, B Baranowski, P Aziz… - Circulation: Arrhythmia …, 2016 - Am Heart Assoc
2 Aagaard et al Early Repolarization in Athletes 8% to 44%, which is considerably higher
than in the general population (Table). 10, 18, 21, 27–30 In an elegant study design …

Early repolarization in adolescent athletes: A gender comparison of ECG and echocardiographic characteristics

M Vecchiato, V Baioccato, PE Adami… - … Journal of Medicine …, 2022 - Wiley Online Library
Background The early repolarization pattern (ERp) is an electrocardiographic finding
previously associated with arrhythmic risk in adults. The purpose of this study is to evaluate …

[HTML][HTML] Gender differences in the 12-lead electrocardiogram: clinical implications and prospects

V Carbone, F Guarnaccia, G Carbone… - Journal of Sex-and …, 2020 - gendermedjournal.it
Many sex differences exist in cardiac electrophysiology which are reflected on surface ECG.
All gender-related differences in the repolarization features, including QT duration, J-ST …