Lessons from the host defences of bats, a unique viral reservoir

AT Irving, M Ahn, G Goh, DE Anderson, LF Wang - Nature, 2021 - nature.com
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …

Viruses in bats and potential spillover to animals and humans

LF Wang, DE Anderson - Current opinion in virology, 2019 - Elsevier
Highlights•Bats are a very important source of emerging viruses.•Bat coronavirus, filovirus,
paramyxovirus and reovirus are known zoonotic viruses.•Many of the emergent bat viruses …

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike …

AD Davidson, MK Williamson, S Lewis, D Shoemark… - Genome medicine, 2020 - Springer
Background SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly
impacted global human health. We wanted to rapidly characterise the transcriptomic …

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

M Ahn, DE Anderson, Q Zhang, CW Tan, BL Lim… - Nature …, 2019 - nature.com
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …

Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats

P Zhou, M Tachedjian, JW Wynne… - Proceedings of the …, 2016 - National Acad Sciences
Bats harbor many emerging and reemerging viruses, several of which are highly pathogenic
in other mammals but cause no clinical signs of disease in bats. To determine the role of …

Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

MW Carroll, DA Matthews, JA Hiscox, MJ Elmore… - Nature, 2015 - nature.com
West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far
recorded,,. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin …

Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases

M Ahn, VCW Chen, P Rozario, WL Ng, P San Kong… - Cell, 2023 - cell.com
Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

Henipaviruses: an expanding global public health concern?

J Quarleri, V Galvan, MV Delpino - Geroscience, 2022 - Springer
Abstract Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic viruses of
the genus Henipavirus, family Paramyxoviridae that cause severe disease outbreaks in …

When bats go viral: negative framings in virological research imperil bat conservation

A López‐Baucells, R Rocha… - Mammal …, 2018 - Wiley Online Library
The recent upsurge in bat‐borne virus research has attracted substantial news coverage
worldwide. A systematic review of virological literature revealed that bats were described as …

Immunology of bats and their viruses: challenges and opportunities

T Schountz - Viruses, 2014 - mdpi.com
Bats are reservoir hosts of several high-impact viruses that cause significant human
diseases, including Nipah virus, Marburg virus and rabies virus. They also harbor many …