Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …

The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …

Conspectus Treatment of HIV-1 has largely involved targeting viral enzymes using a cocktail
of inhibitors. However, resistance to these inhibitors and toxicity in the long term have …

The conserved noncoding RNA elements in viral genomes interact with proteins to regulate
various events during viral replication. We report studies on the recognition mechanisms of …

Viruses remain a global threat to animals, plants, and humans. The type 1 human
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …

The conserved and structured elements in viral RNA genomes interact with proteins to
regulate various events in the viral life cycle and have become key targets for developing …

RNA represents a potential target for new antiviral therapies, which are urgently needed to
address public health threats such as the human immunodeficiency virus (HIV). We showed …

Being able to effectively target RNA with potent ligands will open up a large number of
potential therapeutic options. The knowledge on how to achieve this is ever expanding but …

DNA and RNA play pivotal roles in life processes by storing and transferring genetic
information, modulating gene expression, and contributing to essential cellular machinery …