During the millions of years they have coexisted with their hosts, viruses have learned how
to manipulate host immune control mechanisms. Viral gene functions provide an overview of …

About a fifth of all human cancers worldwide are caused by infectious agents. In 12% of
cancers, seven different viruses have been causally linked to human oncogenesis: Epstein …

Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is
the etiologic agent of an important disease of cattle in Africa. Here we report the genomic …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

CD8 T cells respond to viral infections but also participate in defense against bacterial and
protozoal infections. In the last few years, as new methods to accurately quantify and …

Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8, is
the etiologic agent underlying Kaposi sarcoma, primary effusion lymphoma, and multicentric …

Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination
pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Poxviruses and gamma-2 herpesviruses share the K3 family of viral immune evasion
proteins that inhibit the surface expression of glycoproteins such as major histocompatibility …

Relatively little is known about immune evasion during the productive phase of infection by
the γ1-herpesvirus Epstein–Barr virus (EBV). The use of a unique system to isolate cells in …