Mechanisms of disease: inflammatory bowel diseases

GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

Genetics of inflammatory bowel diseases

DPB McGovern, S Kugathasan, JH Cho - Gastroenterology, 2015 - Elsevier
In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the …

Curcumin and inflammatory bowel disease: potential and limits of innovative treatments

L Vecchi Brumatti, A Marcuzzi, PM Tricarico, V Zanin… - Molecules, 2014 - mdpi.com
Curcumin belongs to the family of natural compounds collectively called curcuminoids and it
possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and …

[HTML][HTML] Genetics of inflammatory bowel disease from multifactorial to monogenic forms

AM Bianco, M Girardelli… - World journal of …, 2015 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a group of chronic multifactorial disorders. According to
a recent study, the number of IBD association loci is increased to 201, of which 37 and 27 …

[HTML][HTML] Crohn's and colitis in children and adolescents

AS Day, O Ledder, ST Leach… - World journal of …, 2012 - ncbi.nlm.nih.gov
Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases
(IBD). These conditions have become increasingly common in recent years, including in …

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies

A Fierabracci, A Milillo, F Locatelli, D Fruci - Autoimmunity reviews, 2012 - Elsevier
Autoimmune diseases represent a heterogeneous group of conditions whose incidence is
increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a …

Prevalence of apical periodontitis in patients with inflammatory bowel diseases: a retrospective clinical study

V Piras, P Usai, S Mezzena, M Susnik, F Ideo… - Journal of …, 2017 - Elsevier
Aim We evaluated the prevalence of apical periodontitis (AP) and the oral health status in
patients with inflammatory bowel diseases (IBDs) treated with immunomodulators, with …

Identification of variants in genes associated with single-gene inflammatory bowel disease by whole-exome sequencing

JJ Ashton, G Andreoletti, T Coelho… - Inflammatory bowel …, 2016 - academic.oup.com
Background Most cases of inflammatory bowel disease (IBD) are caused by complex host–
environment interaction. There are a number of conditions associated with a single-gene …

Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease

V Marcil, D Sinnett, E Seidman, F Boudreau… - Genes & …, 2012 - nature.com
Hepatocyte nuclear 4 alpha (HNF4α), involved in glucose and lipid metabolism, has been
linked to intestinal inflammation and abnormal mucosal permeability. Moreover, in a …

Dissecting allele architecture of early onset IBD using high-density genotyping

DJ Cutler, ME Zwick, DT Okou, S Prahalad, T Walters… - PloS one, 2015 - journals.plos.org
Background The inflammatory bowel diseases (IBD) are common, complex disorders in
which genetic and environmental factors are believed to interact leading to chronic …