Therapeutic peptides for cancer therapy. Part I–peptide inhibitors of signal transduction cascades
GL Bidwell III, D Raucher - Expert opinion on drug delivery, 2009 - Taylor & Francis
Background: Therapeutic peptides have great potential as anticancer agents owing to their
ease of rational design and target specificity. However, their utility in vivo is limited by low …
ease of rational design and target specificity. However, their utility in vivo is limited by low …
A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1
TC Hart, Y Zhang, MC Gorry, PS Hart, M Cooper… - The American Journal of …, 2002 - cell.com
Hereditary gingival fibromatosis (HGF) is a rare, autosomal dominant form of gingival
overgrowth. Affected individuals have a benign, slowly progressive, nonhemorrhagic, fibrous …
overgrowth. Affected individuals have a benign, slowly progressive, nonhemorrhagic, fibrous …
The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase
M Jaumot, J Yan, J Clyde-Smith, J Sluimer… - Journal of Biological …, 2002 - ASBMB
Ha-Ras and Ki-Ras have different distributions across plasma membrane microdomains.
The Ras C-terminal anchors are primarily responsible for membrane micro-localization, but …
The Ras C-terminal anchors are primarily responsible for membrane micro-localization, but …
Anti-cancer peptides from ras-p21 and p53 proteins
MR Pincus, M Fenelus… - Current …, 2011 - ingentaconnect.com
We have employed computer-based molecular modeling approaches to design peptides
from the ras-p21 and p53 proteins that either induce tumor cell reversion to the …
from the ras-p21 and p53 proteins that either induce tumor cell reversion to the …
Early endosome localization and activity of RasGEF1b, a toll-like receptor-inducible Ras guanine-nucleotide exchange factor
Guanine-nucleotide exchange factors (GEFs) stimulate the intrinsic GDP/GTP exchange
activity of Ras and promote the formation of active Ras–GTP, which in turn controls diverse …
activity of Ras and promote the formation of active Ras–GTP, which in turn controls diverse …
[PDF][PDF] Development of new anti-cancer peptides from conformational energy analysis of the oncogenic ras-p21 protein and its complexes with target proteins
MR Pincus - Front. Biosci, 2004 - article.imrpress.com
Introduction 2.1. Mutated proteins can induce malignant transformation 2.2. Mutant ras-p21
Protein Is a Major Cause of Cancer 2.3. ras-induced signal transduction pathways 2.4. Direct …
Protein Is a Major Cause of Cancer 2.3. ras-induced signal transduction pathways 2.4. Direct …
Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on …
M Kanovsky, J Michl, G Botzolaki, J Morin… - Cancer chemotherapy …, 2003 - Springer
Purpose From molecular modeling studies we found that two ras-p21 peptides,
corresponding to p21 residues 35–47 (PNC-7) and 96–110 (PNC-2), selectively block …
corresponding to p21 residues 35–47 (PNC-7) and 96–110 (PNC-2), selectively block …
Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation
C Kovac, L Chie, J Morin, FK Friedman… - Cancer chemotherapy …, 2001 - Springer
Purpose: We have previously found that a synthetic peptide corresponding to ras-p21
residues 96–110 (PNC2) selectively blocks oncogenic (Val 12-containing) ras-p21 protein …
residues 96–110 (PNC2) selectively blocks oncogenic (Val 12-containing) ras-p21 protein …
Identification, using molecular dynamics, of an effector domain of the ras-binding domain of the raf-p74 protein that is uniquely involved in oncogenic ras-p21 signaling
JM Chen, K Rijhwani, FK Friedman, MJ Hyde… - Journal of Protein …, 2000 - Springer
By comparing the average structures, computed using molecular dynamics, of the ras-
binding domain of raf (RBD) bound to activated wild-type ras-p21 and its homologous …
binding domain of raf (RBD) bound to activated wild-type ras-p21 and its homologous …
Comparison of Molecular Dynamics Averaged Structures for Complexes of Normal and Oncogenic ras-p21 with SOS Nucleotide Exchange Protein, Containing Computed …
T Duncan, JM Chen, FK Friedman, M Hyde, L Chie… - The Protein …, 2004 - Springer
Abstract ras-p21 protein binds to the son-of-sevenless (SOS) guanine nucleotide-exchange
promoter that allows it to exchange GDP for GTP. Previously, we performed molecular …
promoter that allows it to exchange GDP for GTP. Previously, we performed molecular …