Mucosal vaccines—fortifying the frontiers

EC Lavelle, RW Ward - Nature Reviews Immunology, 2022 - nature.com
Mucosal vaccines offer the potential to trigger robust protective immune responses at the
predominant sites of pathogen infection. In principle, the induction of adaptive immunity at …

Heterogeneity of type 2 innate lymphoid cells

H Spits, J Mjösberg - Nature Reviews Immunology, 2022 - nature.com
More than a decade ago, type 2 innate lymphoid cells (ILC2s) were discovered to be
members of a family of innate immune cells consisting of five subsets that form a first line of …

[HTML][HTML] Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

K Golebski, JA Layhadi, U Sahiner, EH Steveling-Klein… - Immunity, 2021 - cell.com
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to
the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 …

Plasticity of innate lymphoid cell subsets

SM Bal, K Golebski, H Spits - Nature Reviews Immunology, 2020 - nature.com
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …

Control of innate immune response by biomaterial surface topography, energy, and stiffness

JO Abaricia, N Farzad, TJ Heath, J Simmons… - Acta Biomaterialia, 2021 - Elsevier
As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

[HTML][HTML] Tissue-specific features of innate lymphoid cells

I Meininger, A Carrasco, A Rao, T Soini, E Kokkinou… - Trends in …, 2020 - cell.com
Although the function of the circulating immune cell compartment has been studied in detail
for decades, limitations in terms of access and cell yields from peripheral tissues have …

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity

CSN Klose, D Artis - Cell research, 2020 - nature.com
The multifaceted organization of the immune system involves not only patrolling
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

JH Bernink, Y Ohne, MBM Teunissen, J Wang… - Nature …, 2019 - nature.com
Here we identify a group 2 innate lymphoid cell (ILC2) subpopulation that can convert into
interleukin-17 (IL-17)-producing NKp44− ILC3-like cells. c-Kit and CCR6 define this ILC2 …

The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma

B Heinrich, EM Gertz, AA Schäffer, A Craig, B Ruf… - Gut, 2022 - gut.bmj.com
Objective Hepatocellular carcinoma (HCC) represents a typical inflammation-associated
cancer. Tissue resident innate lymphoid cells (ILCs) have been suggested to control tumour …

[HTML][HTML] Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

N Alkon, WM Bauer, T Krausgruber, I Goh… - Journal of Allergy and …, 2022 - Elsevier
Background Although ample knowledge exists about phenotype and function of cutaneous T
lymphocytes, much less is known about the lymphocytic components of the skin's innate …