Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Despite thousands of genetic loci identified to date, a large proportion of genetic variation
predisposing to complex disease and traits remains unaccounted for. Advances in …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Estrogens play a major role in the modulation of energy balance through central and
peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP …

Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also
relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and …

Current pharmacological therapies for treating obesity are of limited efficacy. Genetic
ablation or loss of function of AMP-activated protein kinase alpha 1 (AMPKα1) in …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …